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micro rnas in neurodegenerative disorders
专利权人:
THE BRIGHAM AND WOMEN'S HOSPITAL; INC.
发明人:
HOWARD WEINER,OLEG BUTOVSKY
申请号:
BR112014008925
公开号:
BR112014008925A2
申请日:
2012.10.11
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
micrornas in neurodegenerative disorders abstract the invention provides methods for diagnosing neurodegenerative disorders (eg, amyotrophic lateral sclerosis and multiple sclerosis) in a subject, identifying subjects at risk of developing a neurodegenerative disorder, predicting the rate of disease progression in a subject having a neurodegenerative disorder , selecting a subject for treatment of a neurodegenerative disorder, selecting a subject for participation in a clinical study, and determining the efficacy of treatment of a neurodegenerative disorder. These methods include determining the level of one or more micrornas and / or one or more inflammatory markers in a monocyte (eg, a cd14 + cd16- or cd14 + cd16-monocyte) or in cerebrospinal fluid (csf) from the subject and comparing the level of the one or more microwave and / or the level of the one or more inflammatory markers with a reference level (s). also provided are methods of treating a neurodegenerative disorder that include administering to a subject at least one agent that decreases or increases the level of activity or one of more micrornas or one or more inflammatory markers in a monocyte (eg, cd14 + cd16- or cd14 + cd16-monocyte) or in the csf of a subject. ______________________________________________________________ abstract translated below: abstract patent: "micro rnas in neurodegenerative disorders". The invention provides methods for the diagnosis of neurodegenerative disorders (e.g., amyotrophic lateral sclerosis and multiple sclerosis) in an individual, for identifying individuals at risk of developing a neurodegenerative disorder, for predicting the rate of disease progression in an individual. An individual who has a neurodegenerative disorder, for selecting an individual for the treatment of a neurodegenerative disorder, for selecting an individual for participation in a clinical study, and for determining the effectiveness of treatment for a neurodegenerative disorder. These methods i
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