THE INVENTION RELATES TO 6-SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES OF THE FORMULA (I) USEFUL FOR THE TREATMENT AND/OR PREVENTION OF DISEASES ASSOCIATED WITH RHO- KINASE AND/OR RHO-KINASE MEDIATED PHOSPHORYLATION OF MYOSIN LIGHT CHAIN PHOSPHATASE, AND COMPOSITIONS CONTAINING SUCH COMPOUNDS.