KIT OLEG IVANOVICH,Кит Олег Иванович,DZHABAROV FARKHAD RASIMOVICH,Джабаров Фархад Расимович,FRANTSIJANTS ELENA MIKHAJLOVNA,Франциянц Елена Михайловна,ROZENKO LJUBOV JAKOVLEVNA,Розенко Любовь Яковлевна
申请号：
RU2012103769/14
公开号：
RU0002488412C1
申请日:
2012.02.03
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to oncology, and can be used for treating patients with tongue cancer. For this purpose, on the 1st therapeutic day, taxotere 100 mg/m2 and cisplatin 50 mg/m2 are introduced intravenously drop-by-drop. One week later, a primary site and regional metastases are exposed distant gamma-therapy by accelerated fractionation in a single basic dose of 2.4 Gy fractionated by 1.2 Gy every 5 hours to a total basic dose of 40 isoGy. Every second day, in the middle of the 5-hour interval of the separate radiation fractions, platidiam 5 mg dissolved in actovegin gel is administered to the primary site, while the tumour is exposed to ultrasound at frequency 880 kHz and intensity 0.4 Wt/cm2 for 5 minutes. The therapeutic course is 9 administrations. After the 2-week interval of the radiation therapy, the chemotherapy is repeated as specified in the above regimen. The distant gamma-therapy in a single basic dose of 2.4 Gy, 1.2 Gy every 5 hours is conducted to a total basic dose of 60±4 isoGy. Between the radiation fractions, platidiam 5 mg dissolved in actovegin gel is administered to the primary site, while the tumour is exposed to ultrasound at frequency 880 kHz and intensity 0.4 Wt/cm2 for 5 minutes. The therapeutic course is 5 administrations.EFFECT: method provides improving the therapeutic effect and quality of life in the patients with regional tongue cancer, including through a combination of the systemic and local administration of cytotoxic drugs, the effect of sonosensitisation and deeper penetration of the chemotherapeutic preparation into the full-thickness tumour as ensured by the intensive effect of ultrasound with underlying radiation therapy.1 exИзобретение относится к медицине, а именно к онкологии, и может быть использовано для лечения больных раком языка. Для этого в 1-й день лечения вводят таксотер - 100 мг/м2 и цисплатин - 50 мг/м2 внутривенно капельно. Через одну неделю на область первичного очага
