The Trustees of The University of Pennsylvania;Guedan Carrio, Sonia;Novartis AG
发明人:
申请号：
EP15753252.4
公开号：
EP3174546B1
申请日:
2015.07.31
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
This disclosure provides, for instance subset-optimized CART cells and related methods. For instance, the disclosure describes methods and compositions of CD4<；sup>；+<；/sup>；and CD8<；sup>；+<；/sup>；T cells that express CARs containing specific combinations of intracellular signaling domains can be used to increase persistence and anti-tumor activity of the infused CAR-expressing T cells for treating a subject having a disease, e.g., a cancer.
