The present invention relates to new compounds and its pharmaceutical composition, and promote healthy aging, the treatment skin disorder, treatment cardiovascular disorder, treatment kidney disorders, treatment angiogenesis illness such as cancer, the method for treating the myocardial infarction that tissue damage such as non-cardiac tissue leaving a volume damage, treatment are gradually forming and the complication that the various other illnesss for the treatment of are for example generated by what diabetes of skin with the compound of the present invention and composition. Other illnesss may include but unlimited what atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, skin infection, peripheral vascular disease, apoplexy etc..本發明涉及新的化合物和其藥物組合物，以及用本發明的化合物和組合物來促進皮膚的健康老化、治療皮膚病症、治療心血管病症、治療腎病症、治療血管生成病症例如癌症、治療組織損傷例如非心臟組織損傷、治療正在逐漸形成的心肌梗塞和治療各種其他病症例如由於糖尿病而産生的併發症的方法。其他病症可以包括但不限於，動脉粥樣硬化、冠狀動脉病、糖尿病腎病、糖尿病神經病變、糖尿病視網膜病變、皮膚感染、周圍性血管疾病、中風等。
