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Thiophene derivatives useful in the treatment of diabetes
专利权人:
Metabrain Research
发明人:
LEPIFRE, Franck,LENA, Gersande,AUTIER, Valérie,KERGOAT, Micheline,FAVERIEL, Lauren,CHARON, Christine,RAYNAL, Sophie,AUDET, Annick
申请号:
ES13744751
公开号:
ES2600155T3
申请日:
2013.07.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Thiophene derivative of the following general formula I: ** Formula ** where: Y represents an aryl group, a heteroaryl group, or a benzo-1,3-dioxol group, the aryl or heteroaryl group being optionally substituted by one or more groups selected from -CN; a halogen-O atom (C1-C6 alkyl), the alkyl group being optionally substituted by one or more halogen atoms, or by a group -O (C1-C6 alkyl); C1-C6 alkyl substituted by one or more halogen atoms, by a group -O (C1-C6 alkyl), or by a group -OH; -SO2 (C1-C6 alkyl); -CONRaRb where Ra represents a hydrogen atom or a C1-C6 alkyl group and Rb represents a C1-C6 alkyl group; or -OH; X represents a -SO2 group or a group where it represents a bond and W represents an oxygen atom or the -NOR4 group, where R4 represents a hydrogen atom, a C1-C6 alkyl group or an aryl (C1-C6 alkyl) group , the aryl group being optionally substituted by one or more groups selected from -CN; a halogen atom; -O (C1-C60 alkyl), the aryl group being optionally substituted by one or more halogen atoms, or by a group -O (C1-C6 alkyl); C1-C6 alkyl substituted by one or more halogen atoms, by a group -O (C1-C6 alkyl), or by a group -OH; -SO2 (C1-C6 alkyl); -CONRa'Rb 'where Ra' represents a hydrogen atom or a C1-C6 alkyl group and Rb 'represents a C1-C6 alkyl group, or -OH, or is absent and W represents -OH; R1 represents - a C1-C6 alkyl group, the aryl group being optionally substituted by a halogen atom; - a C3-C6 cycloalkyl group; - a group (C1-C6 alkyl) O (C1-C6 alkyl); - a group (C1-C6 alkyl) NR (C1-C6 alkyl) where R represents a hydrogen atom or a C1-C6 alkyl group, - an aryl group, the aryl group being optionally substituted by one or more groups selected from - -CN; a halogen atom; -O (C1-C60 alkyl), the aryl group being optionally substituted by one or more halogen atoms, or by a group -O (C1-C6 alkyl); -SO2 (C1-C6 alkyl); -CONRa "Rb" where Ra "represents a hydrogen atom or a C1-C6 alkyl group and Rb" represents a C1-C6 alkyl group; or C1-C6 alkyl),
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