Conny Gysemans;Joao Paulo Monteiro Carvalho Mori CUNHA;Chantal Mathieu
发明人:
Joao Paulo Monteiro Carvalho Mori CUNHA,Conny Gysemans,Chantal Mathieu
申请号：
US15147563
公开号：
US20160326494A1
申请日:
2016.05.05
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides methods that increases the graft survival rate of pancreatic islets after pancreatic islet transplantation, maintains the survival of pancreatic islets ex vivo, and reduce the number of transplanted pancreatic islets required for normalizing blood glucose levels. When performing pancreatic islet transplantation, by contacting pancreatic islets with stem cells or by transplanting pancreatic islets and stem cells in contact with each other, it is possible to significantly improve graft survival rate of transplanted pancreatic islets and reduce the number of transplanted pancreatic islets required for normalizing blood glucose levels. The invention also provides compositions for pancreatic islet transplantation comprising the islets and the stem cells or conditioned medium from stem cell culture islets. Thus, the composition and methods are useful for treating diabetes.
