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COMPOSITIONS, KITS AND METHODS FOR TREATMENT OF CARDIOVASCULAR, IMMUNOLOGICAL AND INFLAMMATORY DISEASES
专利权人:
Nanette Bishopric;Jing Liu;Salil Sharma;Lina Shehadeh
发明人:
Nanette Bishopric,Lina Shehadeh,Jing Liu,Salil Sharma
申请号:
US13884060
公开号:
US20130236437A1
申请日:
2011.11.11
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Compositions, kits, cells and methods for treating cardiovascular (e.g., myocardial ischemia and heart failure), immunological, and inflammatory diseases or disorders involve the use of the mature and precursor sequences of microRNAs 142-5p, 142-3p, 17-5p, 17-3p, 374, and 20a, and of antisense molecules complementary to these sequences, to manipulate processes relevant to, for example, the cardiac response to stress, including survival signaling, angiogenesis, stem cell differentiation along muscle or vascular lineages, and repression or promotion of cardiac myocyte growth. Also described are methods to treat cardiovascular, immunological and inflammatory diseases by engineering cells containing specific micro-RNAs or antagomirs against specific mRNAs. The engineered cells can then be used to treat patients with such diseases by autologous stem cell therapy.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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