Marko MIHOVILOVIC,Thomas LINDER,Verena M. DIRSCH,Atanas ATANASOV,David BERNHARD,Herrmann STUPPNER,Stefan SCHWAIGER
申请号：
US15322107
公开号：
US20170157301A1
申请日:
2015.06.24
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A compound of formula (II), and a method of preparation thereof, for use as a smooth muscle cell (SMC) proliferation-inhibiting drug:wherein: R1 to R6 are —H, —F, —CH3, —CF3, —CF2CH3, —OCH3, —COCH3, —C4H9, —COOC2H5, or —C6H5, or two vicinal residues from R1 to R6 form a saturated or unsaturated carbocyclic ring together with the two carbon atoms to which they are attached R7 is OH, allyloxy, propargyl-oxy, 2,2-dimethylpropanoyloxy (pivaloyloxy), butanoyloxy, 3-methylbutanoyloxy, 2-buten-oyloxy, 2-methyl-2-butenoyloxy, 3-methyl-2-butenoyloxy, isopentanoyloxy, 2-ethylbutanoyl-oxy, 3,3-dimethylbutanoyloxy, cyclopropylcarbonyloxy, cyclobutylcarbonyloxy, cyclo-pentylcarbonyloxy, cyclopentenylcarbonyloxy, cyclohexylcarbonyloxy, cyclo-hexenylcarbonyloxy, adamantylethanoyloxy, 3-phenylpropenoyloxy (cinnamyloyloxy), 2-methylbenzoyloxy, or naphthoyloxy wherein, in ring A and/or B, one or more carbon ring atoms are optionally replaced by heteroatoms wherein the compounds of formula (II) are obtained by combining the residues R1 to R7 and which inhibit SMC proliferation at least 50% more effectively than EC proliferation.
