Museum National d'Histoire Naturelle;Institut Curie;Institut National de la Sante et de la Recherch Medicale (INSERM);Centre National De La Recherche Scientifique;Museum National dHistoire Naturelle
发明人:
Dutreix, Marie,SUN, Jian-Sheng
申请号：
AU2008204486
公开号：
AU2008204486B2
申请日:
2008.01.11
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses novel double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as a standalone anticancer drug in an efficient amount to be introduced in the tumor cell nuclei in order to trigger their death.
