It discloses regulation scheme method and induces the chimera of MHC- or HLA-mismatched mixing, by adjusting receptor with radiationless, the cyclophosphamide (CY) of low dosage, Pentostatin (PT) and anti-thymus gland globulin (ATG) donor bone marrow cell before the transplant. In certain embodiments, which can be CD4+ T-depleted bone marrow cells. Regulation scheme and method may also include one or more groups and manage donorcells out of condition selected from donor CD4+ T-depleted splenocytes, donor CD8+ T cells and donor G-CSF-mobilized peripheral blood mononuclear cells. The conditioning regimen clinic can be used for treating the disease and autoimmune disease of inherited blood, and promote immune tolerance in organ transplantation.
