Herman Vromans,Janneke Sophie Groen,Johannes Antonius Hendrikus Van Laarhoven,MARCUS ANTONIUS BERNARDUS KRUFT,Raymond Zeeman,Wouter De Graaff,HERMAN VROMANS,JANNEKE SOPHIE GROEN,JOHANNES
申请号：
BRPI0509146
公开号：
BRPI0509146B1
申请日:
2005.03.16
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
"drug release system, method of manufacture thereof, and use of drug release system". a drug delivery system consisting of one or more compartments and comprising a progestogenic compound dissolved in a thermoplastic poly (ethylene vinyl acetate) copolymer whereby, if the delivery system consists of one compartment, the compartment will comprise (i) ) a core of a thermoplastic poly (ethylene vinyl acetate) copolymer comprising the progestogenic compound, such progestogenic compound being dissolved in the poly (ethylene vinyl acetate) copolymer to a concentration below the saturation level at 25 ° c, and an estrogenic compound； and (ii) a film of a poly (ethylene vinyl acetate) thermoplastic copolymer covering the core, said film being permeable to both compounds； if the delivery system consists of more than one compartment, only one compartment will comprise (iii) the progestogenic compound, such a progestogenic compound being dissolved in a core of a thermoplastic poly (ethylene vinyl acetate) copolymer to a concentration below saturation level at 25 ° C, and an estrogenic compound； and (iv) a film of a poly (ethylene vinyl acetate) thermoplastic copolymer covering the core, said film being permeable to both compounds."sistema de liberação de droga, método de fabricação do mesmo, e, uso do sistema de liberação de droga". um sistema de liberação de droga consistindo de um ou mais compartimentos e compreendendo um composto progestogênico dissolvido em um copolímero termoplástico de poli(etileno-acetato de vinila) segundo o qual, se o sistema de liberação consistir de um compartimento, o compartimento compreenderá (i) um núcleo de um copolímero termoplástico de poli(etileno-acetato de vinila) compreendendo o composto progestogênico, tal composto progestogênico estando dissolvido no copolímero de poli(etileno-acetato de vinila) até uma concentração abaixo do nível de saturação a 25°c, e um composto estrogênico； e (ii) uma película de um copolímero termoplástico de poli
