A PRACTICAL SYNTHESIS OF 9-[2-(R)-HYDROXYPROPYL] ADENINE AND ITS USE IN SYNTHESIS OF ANTI-HIV DRUGS

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专利权人:

发明人:

BRAJA SUNDAR PRADHAN,NARESH VEMPALA,KOMMIREDDY AMARNATH

申请号：

IN1786/MUM/2015

公开号：

IN2015MU01786A

申请日:

2015.05.05

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

The present invention relates to a process of preparing intermediates of Formula I. The process comprises of reacting compound of Formula III with compound of Formula V in the presence of a solvent selected from an alcohol, ether or water to form compound of Formula I. wherein, R1 is selected from –NH2, Cl, Br, NHCOR”, wherein R” is alkyl, aryl, Schiff’s base of formula N=CHR’, wherein R’ is alkyl or aryl R2 is selected from H, alkyl R3 and R4, each independently is H R5 and R6, each independently is H, alkyl R7 is H, alkyl and R8 is H, alkyl.

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