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Composition comprising a compound heterocÍclico And Compound antibiotic and its use to prevent or treat bacterial infections
专利权人:
MUTABILIS
发明人:
申请号:
ARP170102731
公开号:
AR109773A1
申请日:
2017.09.29
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
Claim 1: Composition comprising: at least one selected antibiotic aztreonam: amikacin, ciprofloxacin, amoxicillin, chloramphenicol, clindamycin, Colistin, cefpirome,Ceftriaxone, cefotaxime, cefepime, daptomycin, erythromycin, cefixime, Fosfomycin, lmipenem, linezolid, cefuroxime, Cefpodoxime, meropenem, piperacillin, rifampicin, sinercid, tigecycline,Vancomycin, sulbactama, ceftaroline, cefiderocol (S - 649266) or bal30072; and at least one Compound of formula (1), where r is selected from - so₃h or cf₂co₂h; r¹ is selected from h, ch₂ - nh₂,Conh₂ or a heteroaryl 5 members comprising at least two nitrogens; b is a remainder formula (2) or is ch₂ and B is c = nor⁴; R² is a hydrogen Atom or a 4 to 10 Member heterocycleS partially or fully saturated, unsaturated and aromatic, which comprises at least one nitrogen Atom, unsubstituted or substituted with one or more t¹, preferably not replaced; r³ is H,Or oxazolilo; or R² and r³ along with the carbon Atom to which they are United to form a selected Cycle: the remains of formula (3) or formula (4), where y is s u s or, preferably,And r⁵ is c₂₋₃ alkyl - nh₂; r⁴ is ₂nh₂ (ch₂) - or - ch₂conh₂; t¹, identical or different,Independently represents a Fluorine Atom; (ₘoq¹ ch₂); (ch₂) ₘ - CN, - (ch₂) ₘ OC - (OR) - (q¹; ₘ ch₂) - C (o) - (oq¹; ch₂) ₘ OC - (OR) - (ch₂) ₘ oq¹; nq¹q²; OC - (OR) - (ₘ ch₂) - C (o) - (ₘ nq¹q²; ch₂) - C (o) - (onq¹q²; ch₂) - C (ₘNq¹oq² - (OR); ₘ ch₂) - C (o) - nq¹ nq¹q²; - (ch₂ ₘ nq¹c) - (OR) - (q²; ch₂ ₘ nq¹s) - (OR) - (₂nq¹q²; ch₂ ₘ nq¹s) - (OR) - (₂q²; ₘ ch₂) - S (o) ₂nq¹q²; - (ch₂ ₘ nq¹c) - (OR) - (oq²; ch₂ ₘ nq¹c) - (OR) - (nq¹q²; ch₂) ₘ - nq¹q²; - (ch₂) ₘ - NH - C (= nhq³ nq⁴ - (CH);₂) ₘ - NH - ch = nq³; - (ch₂ ₘ) - C (= nq⁴ nhq³); (X) - (ₚoq¹ ch₂); (X) - (-) - ₙ ch₂); (X) - (ch₂) ₚ - OC (or q¹; (X) ₙ) - (ch₂) - C (o) - oq¹; (X) - (ch₂) ₚ - OC (or oq¹); (X) - (ch₂) ₚ - OC (or nq¹q²); (X) - (ₙ ch₂) - C (o) - (X nq¹q²; ₙ) - (ch₂) - C (o) onq¹q); (X) - (ₙ ch₂) - C (o) - nq¹oq²; (X) - (ₙ ch₂) - C (o) - nq
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