The invention provides an indoor livestock confinement system that includes a plurality of hollow plastic panels. Each panel includes a plurality of spaced tabs at its ends. A first end of each panel includes a first set of tabs, and a second end of each panel includes a second set of tabs. Each set of tabs includes at least one tab at a top portion of the end, at least one tab at an intermediate portion of the end, and at least one tab at a lower portion of the end. The tabs of the first set are offset vertically from the tabs of the second set such that the first set of tabs of a first panel fit vertically between the second tabs of another panel when the ends of the panels are put together. Each tab includes a hole such that a rod can be inserted down through the tabs to lock the panels together. The livestock confinement system may include additional features, such as ventilation components, reinforced panels, and bucket holders.