A method of reducing cell damage can include inserting device into a blood vessel, wherein the device includes a hollow shaft, a lumen, a fluid directing portion comprising a U-shaped lateral orifice extending between the exterior and interior surfaces and a corresponding U-shaped diverter adjacent to the U-shaped lateral orifice, wherein the diverter is disposed within the lumen and transverse to the central axis, and decreasing free plasma hemoglobin levels, thereby reducing damage to circulating blood cells or endothelium during dialysis.
