BRUCE VARIANO,JEFFREY SPECK,MARIA TERESA SALLENT,SIMONE EVANS
申请号：
BR112012001353
公开号：
BR112012001353A2
申请日:
2010.04.07
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
Multi-layered vaginal rings 2 comprising silicone elastomers and pharmaceutically active ingredients are disclosed. The rings comprise a number of layers, at least one of which contains a pharmaceutically active ingredient, and each of which is a silicone elastomer. The multiple layers preferably are produced from these layers of different compositions, including an inner layer 4, a middle layer 5, and an outer layer 6. After extrusion and simultaneous curing, however, the ring 2 includes a contiguous body which comprises a continuous silicone body providing unimpeded diffusion of the pharmaceutically active ingredient from the inner layer (s) 4 to the outer layer (s) 6. Methods of producing these vaginal rings and of using them are also disclosed.
