您的位置: 首页 > 农业专利 > 详情页

Method for producing tricyclic derivative
专利权人:
ジェ イル ファーマシューティカル カンパニー リミテッド
发明人:
キム,ミョン-ファ,イェ,イン-ヘ,チェ,ジョン-ヒ,キム,ミョン-ファ,イェ,イン-ヘ,チェ,ジョン-ヒ
申请号:
JP2012517404
公开号:
JP5457555B2
申请日:
2010.06.29
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
The present invention relates to a method for preparing a tricyclic derivative, and more particulary, to a method for preparing a tricyclic derivative inetermediate with high yield and purity, the method including: introducing a hydroxy group by esterifying and substituting 2-fluoroisophthalic acid compound; introducing a piperidyl group; introducing a hydroxy group through reduction reaction; and then hydrolyzing the resultant compound, and to a method for preparing the tricyclic derivative using said intermediate. According to the method of the present invention, it is possible to provide a tricyclic derivative and an intermediate thereof with high productivity and economic feasibility as well as high purity and yield, by purifying a compound using re-crystallization unlike typical methods of using column chromatography. In addition, the method of the present invention can be usefully used for industrial mass production because sodium borohydride or lithium aluminum hydride with low risk of a fire is used unlike typical methods of using lithium borohydride which is not industrially applicable due to high risk of a fire.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充