#$%^&*AU2012202717A120120531.pdf#####Abstract Water-insoluble matrix tablets which are capable of prolonged release of active principles liable to be diverted for drug addiction purposes, the said active principles being dispersed within a compression matrix wherein said matrix represents 50 to 98 weight % of the total weight of said tablet and contains at least one excipient selected from the group consisting of sustained-release, water-insoluble, pH-independent, polymers, mineral excipients and their mixtures and one or more of the following substances (a) to (f) or mixtures thereof: (a) a substance which irritates the nasal and/or pharyngeal tracts, (b) a viscosity-increasing agent, leading to formation of a gel when the tablet is dissolved in a minimum amount of water, (c) an emetic substance, (d) an aversive colouring agent, (e) a bittering-substance, (f) an antagonist of the active ingredient(s) which may be the subject of drug abuse.1/12 Figure 1 Dissolution profiles at pH 6.8 of non-film coated 40 mg oxycodone HCl tablets, obtained according to Example 1. Dissolution profile of tablet batch XCOX5009 in 900 mL medium pH 6.8 (paddles, 100 rpm) 100 80 -______________________________ _ 80 0 40 20 0 0 4 8 12 16 20 24 Time (hrs) Figure 2 Dissolution profiles at pH 6.8 of non-film coated 40 mg oxycodone HCl tablets, obtained according to Example 2. Dissolution profile of tablet batch XCOX5111 In 900 mL medium pH 6.8 (paddles, 100 rpm) 100 80 * 60 0 4020 0 0 4 8 12 16 20 24 Time (hr)
