A head mounted display (HMD) system includes an HMD device worn on a head of a user. The HMD device incorporates electroencephalography (EEG) interfaces for monitoring the brain of a human subject during interaction with the HMD device. Fluctuations in electrical potential that are observed via the EEG interfaces may be used to detect event-related potentials (ERPs). The HMD system may programmatically perform one or more operations in response to detecting ERPs. The HMD system may further include off-board devices that communicate with the HMD device over a wireless communications network.