您的位置: 首页 > 农业专利 > 详情页

SELEXIPAG FORMULATION IN LIQUISOLID SYSTEM
专利权人:
发明人:
申请号:
EP16204499.4
公开号:
EP3335699A1
申请日:
2016.12.15
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present invention relates to a process for the preparation of a liquisolid powder, wherein the process comprises the steps of providing a solution comprising 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-(isopropylamino]butoxy}-N-(methanesulfonyl)acetamide (selexipag) and a solvent, wherein said solvent is a non-volatile solvent, a mixture of non-volatile solvents, or a mixture of non-volatile and volatile solvents, to form a solution comprising selexipag and mixing the solution thus obtained with a solid porous carrier, thereby obtaining a liquisolid powder.The present invention further refers to a process for the preparation of a solid final dosage form, comprising the additional step of formulating the liquisolid powder in a final dosage form.The present invention also relates to a liquisolid powder comprising selexipag, a final dosage form comprising the liquisolid powder, and the use thereof in a method of prevention or treatment of pulmonal arterial hypertension.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充