The present invention provides a cancer treatment method in which side effects are inhibited. Specifically, in a combination therapy of a high intensity focused ultrasound therapy at an irradiation intensity of 320 to 700 W/cm2 and an anti-cancer agent therapy, an anti-cancer agent containing an anthracycline is used such that the anthracycline in a dose of 0.5 to 7.5 mg/kg body weight is administered to a cancer patient.