Joshua P. FREDERICK,Ailin BAI,Vladimir PRESNYAK,Stephen G. HOGE,Kerry BENENATO,Iain MCFADYEN,Ellalahewage Sathyajith KUMARASINGHE,Susannah HEWITT
申请号：
US16543102
公开号：
US20200113844A1
申请日:
2019.08.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
