Bio selective textured surfaces are described which mediate foreign body response, bacterial adhesion, and tissue adhesion on devices implanted in a mammalian body. Hierarchical levels of texture, some capable of establishing a Wenzel state others a Cassie state, are employed to interface with living structures, either to promote or discourage a particular biological response/interaction. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and a desired interaction state evolves.本發明描述具生物選擇性結構之表面，其傳介植入哺乳動物體內之裝置上的外來物體反應、細菌黏附及組織黏附。該具生物選擇性結構之表面採用遞階多層次結構(有些能夠建立Wenzel狀態，其他能夠建立Cassie狀態)來與存活結構分界以促進或防止特定之生物反應/交互作用。由於傳統上建立Cassie或Wenzel狀態需為氣態，而氣體不會長期留在活組織中，本發明描述類似於上述狀態之組織/裝置交互作用，但該通常以氣體代表之組分被身體成分取代，其中組織成分逐漸分離且逐漸發展出所需之交互作用狀態。
