Dave, Rajesh,Bilgili, Ecevit A.,AZAD, Mohammed A.,TO, Daniel,Knieke, Catharina
申请号：
DK13852722
公开号：
DK2916824T3
申请日:
2013.11.08
申请国别(地区):
DK
年份:
2019
代理人:
摘要：
A composite particle including a core with at least one carrier material； a fluidizing material layer on the surface of the core； and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material； preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material； and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.
