Isolation and use of human lymphoid organ-derived suppressive stromal cells

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专利权人:

The General Hospital Corporation D/B/A Massachusetts General Hospital;Dana-Farber Cancer Institute, Inc.

发明人:

Fletcher, Anne,Turley, Shannon J.,Parekkadan, Biju

申请号：

AU2013235600

公开号：

AU2013235600A1

申请日:

2013.03.13

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

A method for suppressing an immune response is provided. The method involves administration of isolated lymphoid tissue-derived suppressive stromal cells (LSSC) to a subject in need of such treatment in an amount effective to suppress the immune response in the subject. The invention also involves a method to isolate LSSC by digesting lymphoid tissue fragments using a combination of an enzyme mix and agitation and then collecting the LSSC. Pharmaceutical preparations comprising LSSC are also provided.

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