The present invention relates to a pharmaceutical composition and a method for regenerating a normal tissue from a fibrotic tissue, wherein the pharmaceutical composition comprises a collagen-reducing material. The normal tissue can be therapeutically regenerated from the fibrotic tissue according to the present invention.本發明是關於一種用以從纖維化組織再生正常組織之醫藥組成物及方法,該醫藥組成物中含有膠原蛋白減少物質。藉由本發明,而能夠從纖維化組織治療性地再生正常組織。