ENZASTAURINE ET AGENTS AUGMENTANT L'ACTIVITE DU GENE FHIT (FRAGILE HISTIDINE TRIAD) POUR LE TRAITEMENT DE L'HYPERTENSION PULMONAIRE (PAH)

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专利权人:

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人:

SPIEKERKOETTER, EDDA,DANNEWITZ PROSSEDA, SVENJA,TIAN, XUEFEI,KHATRI, PURVESH

申请号：

CA3064275

公开号：

CA3064275A1

申请日:

2018.05.18

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention provides methods for treatment or prevention of pulmonary hypertension and emphysema using agents that increase activity of FHIT, such as Enzastaurin. Included are methods for using levels of FHIT and/or BMPR2, and checking for mutations in FHIT and/or BMPR2, to select patients for treatment or to monitor effectiveness of treatment. The invention is based on evidence that by Enzastaurin prevents and reverses pulmonary hypertension induced in animal model systems, and that it acts by up-regulation of FHIT and/or BMPR2.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/