Disclosed are a handle assembly and an anastomat comprising the handle assembly. The handle assembly comprises: a pointer (4)； a first handle (1) and a second handle (2)； a sliding groove (17) and a sliding block (3) located on the first handle (1), with the pointer (4) driving the sliding block (3) to slide from a first section of the sliding groove (17) to a second section of the sliding groove (17) when moving from a first location area to a second location area； when the sliding block (3) is located at the first section of the sliding groove (17) and the first handle (1) rotates in a first direction, the sliding block (3) is not in contact with the second handle (2), and the second handle (2) is in a secured position； and when the sliding block (3) is located at the second section of the sliding groove (17) and the first handle (1) rotates in the first direction, the sliding block (3) drives the second handle (2) to move towards a triggering position. The handle assembly comprises a first handle (1) and a second handle (2), and only the movement of the second handle (2) can trigger the anastomat to perform cutting and stitching actions. The doctor can press the first handle (1) regardless of whether or not the anastomat has reached a triggerable position； however, when the anastomat does not reach the triggerable state, the first handle (1) will not drive the second handle (2), so that the anastomat will not be triggered.L'invention concerne un ensemble poignée et un dispositif d'anastomose comprenant l'ensemble poignée. L'ensemble poignée comprend : un pointeur (4) ； une première poignée (1) et une seconde poignée (2) ； une rainure de coulissement (17) et un bloc coulissant (3) situé sur la première poignée (1), le pointeur (4) entraînant le bloc coulissant (3) pour le faire coulisser d'une première section de la rainure de coulissement (17) à une seconde section de la rainure de coulissement (17) lors du déplacement d'une première zone de localisation à une se
