Substituted pyridine-2-carboxamide compounds as apoptosis signal-regulating kinase inhibitors

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专利权人:

Inc.;Gilead Sciences

发明人:

Notte, Gregory

申请号：

AU2016247182

公开号：

AU2016247182A1

申请日:

2016.10.21

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

#$%^&*AU2016247182A120161110.pdf#####ABSTRACT The present invention relates to compounds of Formula (I) wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase ("ASKl") inhibitory activity, and are thus useful in the treatment of ASK1 -mediated conditions, including 5 autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases. N R 4 0R S N, R N Ri N R I R5 Rb (I)

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