SIEGE DOTE D'UN MECANISME DE VERROUILLAGE D'INCLINAISON

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专利权人:

LANTHIOPEP B.V.

发明人:

RINK, RICK

申请号：

CA2941080

公开号：

CA2941080A1

申请日:

2015.03.25

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

The invention relates to the field of pharmacology. In particular, it relates to novel analogs of apelin, and to the therapeutic uses thereof. Provided is cyclic apelin analog of the general formula X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13- X14, comprising a Lanthionine bridge of the structure Ala-S-Ala or a methylLanthionine bridge of the structure Abu-S-Ala or Ala-S-Abu and wherein said (methyl)Lanthionine bridge is of the size i, i+3； i, i+4, i, i+5 or i, i+6.

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