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4-氨基-2-(1H-吡唑並[3,4-B]吡啶-3-基)-6-氧代-6,7-二氫-5H-吡咯並[2,3-D]嘧啶衍生物及其相應的(1H-吲唑-3-基)衍生物作為治療心血管疾病的CGMP調節劑
专利权人:
Merck Sharp & Dohme Corp.
发明人:
BERGER, Raphelle,CHEN, Yi-Heng,LI, Guoqing,GARFUNKLE, Joie,LI, Hong,MIAO, Shouwu,RAGHAVAN, Subharekha,SMITH, Cameron, J.,STELMACH, John,WHITEHEAD, Alan,ZHANG, Rui,ZHANG, Yong,FU, Jianmin,JI, Gang,JIAN
申请号:
HK18114149
公开号:
HK1255028A1
申请日:
2018.11.06
申请国别(地区):
HK
年份:
2019
代理人:
摘要:
or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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