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Therapeutic agents comprising insulin and elastin-like peptides
专利权人:
Ashutosh Chilkoti
发明人:
Ashutosh Chilkoti
申请号:
US13524812
公开号:
US09127047B2
申请日:
2012.06.15
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistence in the body, solubility, and bioavailability.
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中国工程科技知识中心
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