The invention relates to curcumin compositions comprising at least 50 mg curcuminoids for administration to healthy subjects, in need thereof, for improving cardiovascular flow. Curcumin compositions as described herein can be administered to subjects in effective dose of 250 mg to 1000 mg, corresponding to about 50 mg to 200 mg curcuminoids, for improvement of endothelial function and reducing risk of cardiovascular diseases. The compositions are comprised of curcumin either alone or along with at least one excipient such as hydrophilic carrier to get curcumin formulation having enhanced absorption. The compositions improve endothelial function in healthy subjects having FMD value of about 5% to 7% and who are not diagnosed with any cardiovascular disease. The composition also improves cardiovascular endothelial function by reducing vascular resistance and enhancing nitric oxide generation in vascular endothelium. Curcumin composition is safe for consumption, possesses enhanced absorption and can be employed for improvement of endothelial function and cardiovascular flow, when administered in effective dose to healthy subjects, in need thereof.
