The invention provides methods and compositions useful for ameliorating age related maladies, enhancing and maintaining immune function, enhancing and maintaining cognitive function, enhancing and maintaining muscle strength, enhancing and maintaining balance, and reducing and mitigating oxidative stress in an animal. The compositions comprise a combination of at least two of one or more unsaturated fatty acids (UFA)； one or more nitric oxide releasing compounds (NORC)； one or more anti-glycation agents； and colostrum, and the methods comprise administering to an animal a therapeutically effective amount of the compositions.
