Jan POOLMAN,Nathalie Isabelle DEVOS,Cindy CASTADO,Vincent WEYNANTS
申请号：
US15370450
公开号：
US20170209562A1
申请日:
2016.12.06
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present disclosure relates to the field of Neisserial immunogenic compositions and vaccines, their manufacture and the use of such compositions in medicine. In particular the present invention relates to compositions and methods involving the factor H binding protein (fHbp) antigen. The present inventors have recognised that fHbp is poorly expressed in neisserial strains of ST269 clonal complex (a subset of strains which seems to be growing in terms of numbers of reported cases of disease attributed to it), and vaccines comprising fHbp may be made more effective against said strains by formulating the vaccine with a further antigen that can elicit protection against these strains.
