ALTMAN, Michael D.,ANDRESEN, Brian,CHANG, Wonsuk,CHILDERS, Matthew Lloyd,CUMMING, Jared N.,HAIDLE, Andrew Marc,HENDERSON, Timothy J.,JEWELL, James P.,LIANG, Rui,LIM, Jongwon,LIU, Hong,LU, Min,NORTHRUP
申请号：
PE2018000235
公开号：
PE20186882A1
申请日:
2016.08.11
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
It refers to silicon dioxide cyclohexane compound (I),（i'）o（i），Basel 1, Basel 2, and existing Basel 1, Xa, x1, XB, xb1, Xc, xc1, XD, XD1, R1, R1a, R2, R2A, R3, R4, R4A, R5, R6, r6a, R7, r7a, R8 and R8a are defined in the description. The preferred compounds are: 2-amino-9 - [(5R, 7R, 7R, 8R, 1R, 15R, 15R, 15R, 15R, 15R, 15R, 15R, 15R, 15R, 15R, 15R, 1r- 1R) - 14 - (7-amino-3h - [7-7-7-3-h - [7-2,3-3-3-h - [7,2,3-3-3-h - [4,5,3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3-3 3,3,3,3,3,3,3,3,3]] tri] tri] tri - -- 15,16-difluoro-difluoro-difluoro-1,9-dihydro-6h-purin-6-one；There are others He also mentioned a pharmaceutical composer These compounds are a class of interfering production inducers that activate Sting's pathway and are useful in dealing with the proliferation of the rotor cells as cancer.SE REFIERE A COMPUESTOS DINUCLEOTIDOS CICLICOS DE FORMULAS (I), (I') O (I"), DONDE BASE1, BASE2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8 y R8a SON COMO SE DEFINEN EN LA DESCRIPCION. SON COMPUESTOS PREFERIDOS: 2-AMINO-9-[(5R,7R,8R,12aR,14R,15S,15aR,16R)-14-(7-AMINO-3H-[1,2,3]TRIAZOLO[4,5-d]PIRIMIDIN-3-IL)-15,16-DIFLUORO-2-HIDROXI-2,10-DIOXIDO-10-SULFANILOCTAHIDRO-12H-5,8-METANOFURO[3,2-l][1,3,9,11,6,2,10]TETRAOXATIADIFOSFACICLOTETRADECIN-7-IL]-1,9-DIHIDRO-6H-PURIN-6-ONA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INDUCTORES DE LA PRODUCCION DE INTERFERON DE TIPO I QUE ACTIVAN LA VIA DE STING SIENDO UTILES EN EL TRATAMIENTO DE TRANSTORNOS DE PROLIFERACION CELULAR COMO CANCER
