Medical sensor assemblies configured to provide enhanced patient comfort when worn over a period of time are provided. The medical sensor assemblies may include sensors in optical communication with one or more biodegradable light guides that facilitate the transmission of light to and from an internal tissue of the patient. The medical sensor assemblies may also include a bandage that facilitates coupling of the light guides to the sensor. Additionally or alternatively, a bandage may be positioned against an internal tissue to specifically direct the emitted light through the tissue. Such embodiments may provide enhanced light transmission between the emitter and detector of the sensors.
