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1,2-Cyclohexandiaminplatin(II) bis-(4-methylbenzolsulfonat) und dessen Hydrate
专利权人:
HERAEUS PRECIOUS METALS GMBH & CO. KG
发明人:
JOST, STEFFEN,BRANDES CHRISTIAN,RAUTER, HOLGER,WERNER SILVIA,SCHMENGLER STEFANIE
申请号:
EP12008120.3
公开号:
EP2740737A1
申请日:
2012.12.05
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Beschrieben wird das Dihydrat von 1,2-Cyclohexandiaminplatin(II)bis-(4-methylbenzolsulfonat), ein Verfahren zur Herstellung von 1,2-Cyclohexandiaminplatin(II)bis-(4-methylbenzolsulfonat) und dessen Hydraten sowie die Verwendung von 1,2-Cyclohexandiaminplatin(II)bis-(4-methylbenzolsulfonat) und dessen Hydraten.1,2-Cyclohexanediamine platinum(II) bis-(4-methylbenzene sulfonate) dihydrate (A), is new. Independent claims are also included for: (1) preparing (A) (2) using 1,2-cyclohexanediamine platinum(II) bis-(4-methylbenzene sulfonate) and its hydrates as a reference standard for (SP-4-2)-diaqua[(1R, 2R)-cyclohexane-1,2-diamine-kappa-N,kappa-N] platinum, comprising (i) providing a solution of oxaliplatinum, (ii) providing a solution of 1,2-cyclohexanediamine platinum(II) bis-(4-methylbenzene sulfonate) or its hydrate as the reference standard, (iii) carrying out chromatographic absorption of oxaliplatinum solution from step (i), (iv) carrying out chromatographic absorption of the reference standard solution from the step (ii), and, (v) comparing chromatographic absorption from the steps (iii) and (iv) to determine the amount of (SP-4-2)-diaqua [(1R, 2R)-cyclohexane-1,2-diamine-kappa-N, kappa-N?]platinum and (3) using 1,2-cyclohexanediamine platinum(II) bis-(4-methylbenzene sulfonate) and its hydrates for producing polymer-bound cyclohexane-platinum(II) complexes, comprising (ia) providing 1,2-cyclohexane diamine platinum(II) bis(4-methylbenzenesulfonate) or its hydrate, (ib) providing the polymer comprising at least one groups, which are introduced into a bond with platinum, (ic) reacting 1,2-cyclohexanediamine platinum(II) bis-(4-methylbenzene sulfonate) or its hydrate with the polymer in a solvent.
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