Novel methods for modulating acute myeloid leukemia stem/progenitor cellexpansionand/or differentiation are disclosed. These methods are based on the use ofaryl hydrocarbon receptor(AhR) modulators and/or compounds of formula I or II(see formula I) (see formula II)Screening assays to identify compounds that may be useful for inhibitingand/or eliminatingAML initiating cells using AhR modulators and/or the compounds of formula I orll are also disclosed.The use of pharmaceutically acceptable agonists of the AhR for preventing orinhibiting minimal residualdisease (MRD) in an AML patient is also disclosed.
