Arvind RAJPAL,Shobha Chowdary POTLURI,Laurent POIROT,Alexandre JUILLERAT,Thomas Charles PERTEL,Donna Marie STONE,Barbra Johnson SASU
申请号：
US15525906
公开号：
US20180044399A1
申请日:
2015.11.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprising an extracellular domain comprising an antigen binding domain, a transmembrane domain, and, an intracellular domain wherein the intracellular domain comprises an Immunoreceptor Tyrosine-based Switch Motif ITSM, wherein said ITSM is a sequence of amino acid TX1YX2X3X4, wherein X1 is an amino acid X2 is an amino acid X3 is an amino acid and X4 is V or
