特異性針對PD1及TIM3之雙特異性抗體农业专利-农业学术服务平台

发明人:: CODARRI-DEAK, LAURA,柯达瑞－迪克　萝拉,柯達瑞－迪克　蘿拉,FERTIG, GEORG,福堤格　基亚格,福堤格　基亞格,FISCHER, JENS,费雪　詹斯,費雪　詹斯,KLEIN, CHRISTIAN,克连　克利斯添,克連　克利斯添,LEVITSKI, VIKTOR,乐菲斯基　维克特,樂菲斯基　維克特,LIFKE, VALERIA,利夫卡　凡立瑞亚,利夫卡　凡立瑞亞,PER,柯达瑞-迪克萝拉,柯達瑞-迪克蘿拉,福堤格基亚格,福堤格基亞格,费雪詹斯,費雪詹斯,克连克利斯添,克連克利斯添,乐菲斯基维克特,樂菲斯基維克特,利夫卡凡立瑞亚,利夫卡凡立瑞亞

摘要：: The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.本發明係關於包含特異性結合於PD1之第一抗原結合位點及特異性結合於TIM3之第二抗原結合位點的雙特異性抗體，尤其如下雙特異性抗體，其中該雙特異性抗體以低於結合於PD1之結合親和力結合於TIM3。本發明進一步關於產生此等分子之方法及其使用方法。