A topically administrable pain relief formulation comprises a Kunzea ambigua extract or one or more components or derivatives thereof； Menthol； Capsaicin； and a Hypericum perforatum extract or one or more components or derivatives thereof. The formulation may further comprise methyl salicylate, black pepper and/or an anti-inflammatory agent. The formulation may be used to treat or prevent pain such as arthritis neck pain, shoulder pain, back pain, preoperative and/or postoperative pain and pain associated with minor or traumatic injuries or other diseases or conditions.
