您的位置: 首页 > 农业专利 > 详情页

Specific binding agents of the hepatocyte growth factor
专利权人:
AMGEN INC.;ABGENIX, INC.
发明人:
申请号:
ARP120101798
公开号:
AR086510A2
申请日:
2012.05.21
申请国别(地区):
AR
年份:
2013
代理人:
摘要:
Claim 3: isolated an Antibody capable of binding to a Chimeric human / mouse HGF polypeptide, wherein the Chimeric polypeptide Molecule comprises a Mouse HGF has 507 - 585 amino acids of Human HGF in place of the sequence homologous to Mouse, and where The Antibody does not bind significantly to Mouse HGF,And where the Antibody is capable of neutralizing the binding of HGF to c-met.Claim 5: a host Cell comprising a First polinucle u00f3tido encoding a light chain and a heavy chain encoding a Second polinucle u00f3tido, wherein the light chain and heavy chain are capable of forming an Antibody that can bind at least one polypr u00e9ptido is selected in an amino acid sequence of SEQ ID no. 164 and 165And where the Antibody is capable of neutralizing the binding of HGF to c-met.Claim 7: a host Cell comprising a First polinucle u00f3tido encoding a light chain and a heavy chain encoding a Second polinucle u00f3tido, wherein the light chain and heavy chain are capable of forming an Antibody that can bind to a polip u00e9pti Chimeric human / mouse HGF do,Chimeric polypeptide comprising a Molecule where the mouse HGF has 507 - 585 amino acids of Human HGF in place of the sequence homologous to Mouse, where the Antibody does not bind significantly to Mouse HGF, and where the Antibody is capable of neutralizing the joined N to HGF c-met.Claim 9: using the Antibody according to any one of claims 1 to 4, characterized in that it is for the manufacture of a Medicament for the treatment of cancer.Reivindicación 3: Un anticuerpo aislado capaz de unirse a un polipéptido HGF quimérico humano/ratón, caracterizado porque el polipéptido quimérico comprende una molécula HGF de ratón que tiene los aminoácidos 507 - 585 de la HGF humana en lugar de la secuencia homóloga de ratón, y donde el anticuerpo no se une de manera significativa a una HGF de ratón, y donde el anticuerpo es capaz de neutralizar la unión de HGF a c-Met.Reivindicación 5: Una célula huésped que comprende un primer p
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充