LSD1抑制劑之鹽农业专利-农业学术服务平台

发明人:: PAN, YONGCHUN,潘　永春,HAN, WAYNE,韩　韦恩,韓　韋恩,CAO, GANFENG,曹敢峰,FRIETZE, WILLIAM,法里兹　威廉,法里茲　威廉,JIA, ZHONGJIANG,贾　忠将,賈　忠將,SHARIEF, VAQAR,夏夫　瓦克,ZHOU, JIACHENG,周　家谦,周　家謙,LI, QUN,李群,潘永春,韩韦恩,韓韋恩,法里兹威廉,法里茲威廉,贾忠将,賈忠將,夏夫瓦克,周家谦,周家謙

摘要：: The present disclosure relates to tosylate salts 1-{[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piperi din-l-yl]methyl}cyclobutanecarboxylic acid, methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of the LSD1-associated or mediated diseases such as cancer.本發明係關於1-{[4-(甲氧基甲基)-4-({[(1R,2S)-2-苯基環丙基]胺基}甲基)哌啶-1-基]甲基}環丁烷甲酸甲苯磺酸鹽、其製備方法及其製備中之中間物，該等鹽適用於治療LSD1相關或介導之疾病，諸如癌症。