The present invention provides a recombinant human factor H, more particularly a recombinant human factor H represented by the sequence of SEQ ID NO: 1, or the sequence of SEQ ID NO: 1, in a higher yield than the amount of endogenous factor H produced by a human cell line. And the use of said human cell line for the implementation of a method for producing variants having a percentage homology of at least 99%. [Selection figure] None本発明は、ヒト細胞株が産生する内因性Ｈ因子の量より高い収量で、組換えヒトＨ因子、更に特には配列番号１の配列で表わされる組換えヒトＨ因子、又は配列番号１の配列と少なくとも99％の相同性パーセンテージを有する変異体を製造する方法の実施のための該ヒト細胞株の使用に関する。【選択図】なし
