Macrocyclic Compounds, inhibitors of Flaviviridae viruses; Pharmaceutical composition that includes to provide immunomodulation; method; and a method of treating a Flaviviridae selected viral infection of hepatitis B virus infection, hepatitis C virus, Dengue Fever, and Yellow Fever, among others.
STEADMAN VICTORIA ALEXANDRA,POULLENNEC KARINE G.,LAZARIDES LINOS,ACIRO CAROLINE,DEAN DAVID KENNETH,KEATS ANDREW JOHN,SIEGEL DUSTIN SCOTT,SCHRIER ADAM JAMES,MACKMAN RICHARD,JANSA PETR,WATT GREGORY,HIGH
申请号:
CL2014003337
公开号:
CL2014003337A1
申请日:
2014.12.05
申请国别(地区):
CL
年份:
2015
代理人:
摘要:
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.COMPUESTOS MACROCÍCLICOS, INHIBIDORES DE VIRUS FLAVIVIRIDAE; COMPOSICIÓN FARMACÉUTICA; MÉTODO PARA PROPORCIONAR INMUNOMODULACIÓN; Y SU USO PARA EL TRATAMIENTO DE UNA INFECCIÓN VIRAL POR FLAVIVIRIDAE SELECCIONADA DE UNA INFECCIÓN POR VIRUS DE HEPATITIS B, VIRUS DE HEPATITIS C, DENGUE Y FIEBRE AMARILLA, ENTRE OTRAS.