A titration package for enabling compliance with a regimen of changing dosage of an interferon over a period of time, the package comprising interferon-&bgr-1a, delivery devices for said interferon-&bgr-1a, and instructions for intramuscular administration of said interferon-&bgr-1a to a patient during a titration period, wherein the interferon is administered at a dosage of 7.5 micrograms in week one, a dosage of 15 micrograms in week two, a dosage of 22.5 micrograms in week 3, and a dosage of 30 micrograms in week 4.