Identification of cyclic peptide agonists of galanin receptor 2 and 3 guided by spexin solution structure

• 收藏
• 分享

专利权人:

Hong Kong Baptist University

发明人:

Zhaoxiang Bian,Tao Huang,Chengyuan Lin

申请号：

US15925949

公开号：

US10376555B2

申请日:

2018.03.20

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Cyclic peptide agonists toward human galanin receptor 2 (GalR2) and galanin receptor 3 (GalR3) based on hidden conformation of spexin solution structure for GalR2 and GalR3-related and spexin-deficient disorders are designed and synthesized. LH101, LH102, and LH101 (Ac) are potent spexin analogs with prolonged action, which can be used in the treatment of GalR2 and GalR3-related diseases and spexin-deficient disorders, such as obesity.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/