Disclosed is the use of a TGF-&bgr; and/or a TGF-&bgr; degradation product in the preparation of a medicament or a food or drink product for the prevention and/or treatment of wrinkles, sagging, dryness, or roughness of the skin, wherein wrinkles, sagging, dryness, or roughness of the skin is prevented or treated by oral ingestion of the medicament or food or drink product by a subject in need thereof.